Recent breakthroughs are aiming for "cures" by using viruses to deliver functional genes into the patient's liver, allowing the body to produce its own clotting factors.
In the 19th and 20th centuries, it was famously known as the "Royal Disease." Queen Victoria was a carrier and passed the gene to various royal houses across Europe, including the ruling families of Spain, Germany, and Russia. The most famous case was Alexei Nikolaevich, the Tsar’s son, whose condition led the family to seek help from the mystic Rasputin, indirectly impacting the Russian Revolution. Types and Severity bleeder's disease
Also known as "Christmas Disease" (named after the first patient diagnosed with it), caused by a lack of Factor IX . Recent breakthroughs are aiming for "cures" by using