: Understanding why AIRE-deficient individuals develop specific organ-restricted autoimmune diseases. 3. Emerging Therapeutic Perspectives
: Developing treatments like antisense oligonucleotides (ASOs) to reverse abnormal splicing caused by AIRE mutations. daniella aire
: Investigating how AIRE-dependent development of specific "early life" Tregs protects tissues from attack, which could lead to new immunotherapies for T1D and other autoimmune conditions. daniella aire
: For example, researchers have identified unique variants in certain populations, like a deep intronic variant common in patients of Puerto Rican descent. daniella aire