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: STAT proteins bind to these sites and are themselves phosphorylated by JAKs.

The JAK-STAT pathway is a primary intracellular signaling mechanism that mediates the effects of more than 50 cytokines and growth factors. Inhibitors of this pathway, known as or "jakinibs," are small molecules that bind to intracellular Janus kinase enzymes (JAK1, JAK2, JAK3, and TYK2), blocking the downstream activation of STAT proteins and subsequent gene transcription involved in inflammatory and immune responses. Mechanism of Action The JAK-STAT pathway operates in six sequential steps: Download Les inhibiteurs JAK STAT pdf

: Associated JAKs transphosphorylate and activate each other. : STAT proteins bind to these sites and

: A cytokine binds to its transmembrane receptor. Mechanism of Action The JAK-STAT pathway operates in

: STAT dimers translocate to the nucleus to regulate gene expression. Basic Mechanisms of JAK Inhibition - PMC - NIH