Multi-Isoform AKT Signaling: A Systems-Level Analysis of Cellular Homeostasis and Oncogenesis
: Predominantly expressed in the brain, where it regulates organ size and neurodevelopment. 3. Pathological Dysregulation 3.1 Cancer File: AKT_collection_compressed_2022-11-20.zip ...
: Central to cell survival and general growth; its depletion leads to significant transcriptomic shifts in breast cancer cells. File: AKT_collection_compressed_2022-11-20.zip ...
Research indicates that AKT isoforms are not functionally redundant: File: AKT_collection_compressed_2022-11-20.zip ...
We found that changes in the cellular levels of AKT1 lead to changes in the levels of a set of differentially expressed genes and, Akt isoforms in the immune system - Frontiers