[s4e16] House's Head (part 2) -

: Because amantadine binds to proteins, it cannot be cleared via dialysis. House must inform a devastated Wilson that there is no cure. Major Themes

: House deduces that Amber was taking amantadine for the flu. The crash caused acute kidney failure, preventing her body from processing the drug and resulting in lethal amantadine poisoning. [S4E16] House's Head (Part 2)

The finale begins with House suffering from retrograde amnesia following a bus accident. Convinced he witnessed a life-threatening symptom in a fellow passenger before the crash, House undergoes increasingly dangerous procedures—including hypnosis and deep brain stimulation—to retrieve the lost memory. : Because amantadine binds to proteins, it cannot

: House’s subconscious manifests a guide who prompts him to identify the patient. He eventually realizes her necklace is made of amber, signifying that the "dying patient" is actually Amber Volakis , Wilson’s girlfriend. The crash caused acute kidney failure, preventing her