: Despite the shift in plans, the wedding remains a fan favorite, featuring the original "MAGIC" interns (Meredith, Alex, George, Izzie, and Cristina) as the wedding party.
: Jeffrey Dean Morgan makes a final appearance as Denny Duquette, appearing as a hallucination to Izzie that Derek and Bailey eventually realize is a symptom of her worsening condition. Behind the Scenes Facts [S5E22] What a Difference a Day Makes
: Creator Shonda Rhimes noted that Denny's appearance in this episode was meant to represent "Death," which is why he wore black and spoke sparingly compared to previous appearances. : Despite the shift in plans, the wedding
: Alex delivers a powerful, spontaneous speech adapted from a valedictorian's graduation address, promising to be accountable to Izzie through any future challenges. Medical Drama and Character Growth : Despite the shift in plans