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The plot is as literal as its title: after witnessing a murder by a mob boss, Sean Jones (played by Nathan Phillips) is escorted by FBI agent Neville Flynn ( Samuel L. Jackson ) on a flight to Los Angeles to testify. To prevent him from reaching the trial, the mobster unleashes a crate of hundreds of onto the aircraft.
The original script, titled Venom , was inspired by a real-world story about brown tree snakes hitchhiking in airplane cargo during World War II. Snakes on a Plane
Fans were so obsessed with the title that they created their own trailers, posters, and songs before the film even came out. The plot is as literal as its title: