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Upon binding, a "closed" conformation is adopted, where C-terminal domains (C2F, C2G) rearrange. 3. Key Findings in Synaptic Transmission Ca 2+raised to the 2 plus power

Sensing: The C2D domain is identified as critical, as disruptions in this area alter synaptic sound encoding.

The study highlights that membrane binding involves a cooperative effort of multiple domains. tm,cc,jp

Otoferlin engages the target membrane specifically through a large interface involving the N-terminal C2B and C-terminal C2F-C2G domains . Ca 2+raised to the 2 plus power

Based on the 2025 research regarding the protein , which is crucial for hearing and synaptic transmission, Upon binding, a "closed" conformation is adopted, where

The binding requires cooperation between multiple C2 domains to secure the vesicle to the target membrane.

Binding Sites: High-resolution structures revealed that multiple Ca 2+raised to the 2 plus power The study highlights that membrane binding involves a

This molecular mechanism allows the ear to convert sound into neural signals at incredibly high speeds.